MiR-100-3p and miR-877-3p regulate overproduction of IL-8 and IL-1β in mesangial cells activated by secretory IgA from IgA nephropathy patients
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- 作者：Yan Lianga ; b ; Guoqiang Zhaoc ; Lin Tanga ; b ; Junjun Zhanga ; b ; Tianfang Lib ; d ; Zhangsuo Liua ; b ; zhangsuoliu@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：IgAN ; IgA nephropathy ; sIgA ; secretory IgA ; HRMCs ; human renal mesangial cells ; miRNAs ; microRNAs ; UTR ; untranslated region ; IL ; interleukin ; SC ; secretory component ; FITC ; fluorescein isothiocyanate ; P-SIgA ; sIgA from the saliva of patients ; N-SIgA ; sIgA from the saliva of healthy subjects ; MCM ; mesangial cell medium ; qRT-PCR ; quantitative real-time PCR ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; ELISA ; enzyme-linked immunosorbent assay ; MCP-1 ; monocyte chemotactic protein-1 ; TGF-β1 ; tran
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：347
- 期：2
- 页码：312-321
- 全文大小：2891 K
文摘
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56 miRNAs expression in mesangial cells related to IgA nephropathy is shown.
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Overproduction of IL-8 could be regulated by miR-100-3p in mesangial cells.
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MiR-877-3p over-expression could inhibit production of IL-1β in mesangial cells.
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The injury of mesangial cells induced by secretory IgA could be regulated by miRNAs.