Sex and age-dependent effects of a maternal junk food diet on the mu-opioid receptor in rat offspring
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- 作者：Jessica R. Gugusheffa ; Sung Eun Baeb ; Alexandra Raoc ; Iain J. Clarkec ; Lucilla Postonb ; Paul D. Taylorb ; Clive W. Coenb ; Beverly S. Muhlhauslera ; beverly.muhlhausler@adelaide.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; C ; control diet ; JF ; junk food diet ; MuR ; mu-opioid receptor ; NAc ; nucleus accumbens ; PND ; postnatal day ; qRT-PCR ; quantitative real-time PCR ; SEM ; standard error of the mean ; VTA ; ventral tegmental area
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：124-131
- 全文大小：1654 K
文摘
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A maternal junk food (JF) diet alters offspring mu-opioid receptor (MuR) expression.
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It was unclear when these changes in MuR expression in the offspring first emerged.
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No effect of a maternal JF diet on MuR was present on postnatal day 1 or 7.
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Female JF offspring had reduced MuR expression on postnatal day 21 and 28.
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The late suckling period maybe a time of increased susceptibility of MuR to JF diets.