Association of TLR8 gene rs3764880 polymorphisms with susceptibility and lipid metabolism- and inflammation response-related quantitative traits of ischemic stroke in southern Chinese Han male population
详细信息 查看全文
- 作者：Lian Gua ; 1 ; Jinying Zhoua ; 1 ; Jinjing Tana ; 1 ; Junwei Yanga ; Tingting Shena ; Haiyun Jianga ; Qianli Tangb ; tangqianli2015@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：TLR8 ; Polymorphism ; Ischemic stroke ; Lipid ; Inflammation ; Gene expression
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：370
- 期：Complete
- 页码：94-99
- 全文大小：335 K
文摘
- •
816 patients with IS and 816 age- and sex-matched controls were recruited for the study.
- •
The polymorphism was genotyped using Sequenom MassARRAY platform while mRNA expression level was detected by real-time PCR.
- •
Rs3764880 polymorphisms may be association with susceptibility to IS and involved in the inflammatory reaction of males IS.