Determination of pseudoprotodioscin in rat plasma by UPLC-MS/MS: Assay development and application to pharmacokinetic study
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- 作者：Min Liao ; Xiao Chen ; Jiefeng Chen ; Mengping Liu ; Junyi Wang ; Zuanguang Chen ; Zhiyong Xie ; Meicun Yao ; yaomeicun@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pseudoprotodioscin ; UPLC&ndash ; MS/MS ; Method validation ; Rat plasma ; Pharmacokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1026
- 期：Complete
- 页码：97-104
- 全文大小：1284 K
文摘
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Novel UPLC–MS/MS method for quantification of pseudoprotodioscin in rat plasma.
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Lithium adduct ions were employed to enhance the response of the analytes.
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First PK studies of the chemical by oral and intravenous administration in rats.
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The analyte turned out to be rapid excretion and low bioavailability in rats.