Synthesis and conjugation of Sr₂MgSi₂O₇:Eu²⁺, Dy³⁺ water soluble afterglow nanoparticles for photodynamic activation

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• 作者：Homa Homayoni^a ; ^b ; Lun Ma^a ; Junying Zhang^c ; ^{zjy@buaa.edu.cn} ; Sunil K. Sahi^a ; Leila Hossein Rashidi^a ; ^b ; Brian Bui^a ; Wei Chen^a ; ^{weichen@uta.edu}
• 关键词：Sr2MgSi2O7 ; Eu2+ ; Dy3+ ; Sol-Gel ; Water soluble ; Surface coating ; Conjugation ; Afterglow ; Luminescence ; Singlet oxygen ; Cell uptake
• 刊名：Photodiagnosis and Photodynamic Therapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：Complete
• 页码：90-99
• 全文大小：2870 K
• 卷排序：16

文摘

Sr3MgSi2O8:Eu2+, Dy3+ water soluble nanoparticles are synthesized by Sol-Gel method following by coating with APTES. The surface coating with APTES and the conjugation with PpIX and folic acid improve their water solubility. The surface coating and the conjugation also enhance the PpIX luminescence 10 times and singlet oxygen production. The surface coating and conjugation largely increase the cell uptake and greatly reduce their dark cytotoxicity. Sr3MgSi2O8:Eu2+, Dy3+/PPIX/Folic acid nanoconjugates are promising for X-ray induced photodynamic therapy on cancer treatment.