Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers

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• 作者：Gang Chen ; Hongguang Xia ; Yu Cai ; Dawei Ma ; Junying Yuan ; Chengye Yuan
• 关键词：Autophagy ; Diphenylbutylpiperidines ; Synthesis ; SAR study ; Inducers
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2011
• 出版时间：1 January 2011
• 年：2011
• 卷：21
• 期：1
• 页码：234-239
• 全文大小：1902 K

文摘

A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d–e, 15i–j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here.