Selective amyloid β oligomer assay based on abasic site-containing molecular beacon and enzyme-free amplification
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- 作者：Linling Zhu ; Junying Zhang ; Fengyang Wang ; Ya Wang ; Linlin Lu ; Chongchong Feng ; Zhiai Xu ; zaxu@chem.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wen Zhang ; wzhang@chem.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amyloid β ; Oligomer ; Aptamer ; Abasic site ; Molecular beacon
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：206-212
- 全文大小：1880 K
文摘
A label-free molecular beacon (MB) system integrated with enzyme-free amplification strategy was developed for simple and highly selective assay of Aβ oligomers.
Highly selective response for Aβ oligomers.
The method could monitor the Aβ aggregation process.
Without the organic fluorophore labeling for signaling.
Without the use of enzyme for amplification assay.