- 作者：Junyuan Wu ; MM ; Shuo Wang ; MD ; Chunsheng Li ; MD
- 关键词：recurrent ventricular fibrillation ; catecholamine ; blood pressure ; heart rate ; pig
- 刊名：Journal of Emergency Medicine
- 出版年：2013
- 出版时间：February, 2013
- 年：2013
- 卷：44
- 期：2
- 页码：543-549
- 全文大小：228 K
Background
Patients with recurrent ventricular fibrillation (VF) have a high mortality rate, which may be partly due to hemodynamic instability.Objectives
The aim of this study was to simulate spontaneous recurrent VF by repeated induction of VF in pigs, and to evaluate the subsequent changes in heart rate (HR), blood pressure (BP), and serum catecholamine levels.
Methods
VF was induced four times in each of eight female pigs. Defibrillation was first attempted at 30 s after induction of each episode of VF. Circulation was allowed to stabilize for 30 min after return of spontaneous circulation (ROSC) before induction of the next episode of VF. HR and BP were measured before each induction of VF and at 1 min after each ROSC, and venous blood was drawn at the same times to measure serum catecholamine levels.
Results
VF was induced a total of 32?times. Serum epinephrine (EPI) and norepinephrine (NE) levels decreased (p all < 0.05) and dopamine (DA) levels gradually increased (p?<?0.05) with repeated episodes of VF. Compared with baseline values before each episode of VF, BP increased significantly at 1 min after ROSC (p all <?0.05) and then gradually returned to baseline values. HR increased significantly after the first ROSC and stayed elevated. No significant correlations were found between catecholamine levels and HR or BP.
Conclusion
With repeated episodes of VF, BP increased transiently and then gradually returned to baseline values, but HR stayed elevated. Serum DA levels increased, EPI and NE levels gradually decreased.