Does BCG revaccination protect against the development of asthma?

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• 作者：Clá ; udia Ribeiro de Andrade^a ; Sé ; rgio Souza da Cunha^b ; Cristina Gon&ccedil ; alves Alvim^a ; Maria Jussara Fernandes Fontes^a ; Renata Bedran^a ; Henrique A. Binato^a ; Paulo Camargos^a ; ^c ; ^{paulo.camargos@pq.cnpq.br} ; ^{pcamargs@medicina.ufmg.br}
• 关键词：Allergic rhinitis ; Asthma ; BCG vaccination ; Prevalence
• 刊名：Respiratory Medicine
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：107
• 期：2
• 页码：317-319
• 全文大小：116 K

文摘

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Summary

Single BCG vaccination has been considered as a protective factor against asthma. However the effect of a second dose of BCG on the prevalence rate of asthma and asthma-allergic rhinitis-eczema comorbidity has not been studied exclusively among adolescents. In this ISAAC protocol-based cross sectional study we assessed the association between one single versus two doses of BCG among 2213 individuals aged 13-14 years old. We found no association between BCG revaccination and asthma, associated (OR?=?0.68, 95 % CI, 0.37-1.25) or not to allergic rhinitis and/or atopic eczema (OR?=?1.07, 95 % CI, 0.84-1.36).