What's Nu(SAP) in mitosis and cancer?

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• 作者：Jyoti Iyer¹ ; ^a ; Saili Moghe¹ ; ^a ; Manabu Furukawa^a ; Ming-Ying Tsai ; ^a ; ^{mtsai@unmc.edu}
• 关键词：Microtubule ; Importin ; Phosphorylation ; Aurora B ; Polo-like kinase-1 ; Cell division cycle 2
• 刊名：Cellular Signalling
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：23
• 期：6
• 页码：991-998
• 全文大小：641 K

文摘

Unperturbed mitosis is a prerequisite for the generation of two genetically identical daughter cells. Nucleolar-spindle associated protein (NuSAP) is an important mitotic regulator. The activity of NuSAP is essential for a variety of cellular events that occur during mitosis starting from spindle assembly to cytokinesis. In addition to playing crucial roles during mitosis, NuSAP has been in the spotlight recently due to different studies exhibiting its importance in embryogenesis and cancer. In this review, we have extensively mined the current literature and made connections between different studies involving NuSAP. Importantly, we have assembled data pertaining to NuSAP from several proteomic studies and analyzed it thoroughly. Our review focuses on the role of NuSAP in mitosis and cancer, and brings to light several unanswered questions regarding the regulation of NuSAP in mitosis and its role in carcinogenesis.