ID 371 - Single fiber EMG in patients with Myasthenia Gravis

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• 作者：S. Vohá ; ňka^a ; ^b ; M. Chmelí ; ková ; ^a ; J. Bednaří ; k^a ; ^b
• 刊名：Clinical Neurophysiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：127
• 期：3
• 页码：e90
• 全文大小：35 K

文摘

Single fiber electromyography (SFEMG) is a valuable tool in the diagnostics of the neuromuscular transmission. The objective is to evaluate the sensitivity of SFEMG in Myasthenia Gravis (MG).

absSec_2">Patients and methods

The group of 143 patients suffering from MG was examined. Disease was classified as ocular in 26% cases, oculobulbar in 31% cases, and 43% had generalized form. The extramuscular axonal microstimulation technique and registration from the orbicularis oculi muscle was used for the SFEMG end-plate jitter measurement.

absSec_3">Results

Antibodies positivity (anti-AChR or anti-MUSK) was present in 127 patients (89%), but SFEMG was positive in 133 persons (93%). Twelve seronegative patients had positive SFEMG, on the contrary among 10 persons with negative SFEMG the diagnosis was confirmed in 6 cases by positive antibody assay. Only four seronegative patients had also negative SFEMG. The combined diagnostic positivity (antibody assay or SFEMG) was 97%. We did not find any correlation between severity of disease (measured by MGFA ADL score) or the clinical form and jitter abnormalities.

absSec_4">Conclusion

The SFEMG using extramuscular axonal microstimulation of the orbicularis oculi muscle has the high sensitivity and could be recommended as a reliable test for MG regardless of the severity and clinical form.