Multi-scale model for hepatitis C viral load kinetics under treatment with direct acting antivirals
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- 作者：Diana Clausznitzer ; 1 ; Julia Harnisch1 ; diana.clausznitzer@tu-dresden.de" class="auth_mail" title="E-mail the corresponding author ; Lars Kaderali
- 关键词：HCV ; hepatitis C virus
- 刊名：Virus Research
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：218
- 期：Complete
- 页码：96-101
- 全文大小：555 K
文摘
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We developed a multi-scale model of hepatitis C virus infection.
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Patient-level processes and molecular details of viral replication are considered.
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Our model reproduces clinical time-course data of viral load under antiviral treatment.
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We predict treatment efficacy of daclatasvir can be improved by combination therapy.