Characterization and use of (E)-2-[(6-methoxybenzo[d]thiazol-2-ylimino)methyl]phenol as an anion sensor and a DNA-binding agent

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• 作者：Belygona Barare^a ; Mustafa Yıldız^b ; ^c ; ^{myildiz@comu.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; H&uuml ; seyin &Uuml ; nver^d ; Kadir Aslan^a ; ^{kadir.aslan@morgan.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Schiff base ; 2-Amino-6-methoxybenzothiazole ; Spectroscopy ; Calf thymus-DNA ; Anion sensors ; 1H NMR titration
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：3 February 2016
• 年：2016
• 卷：57
• 期：5
• 页码：537-542
• 全文大小：1567 K

文摘

We report the spectroscopic characterization, DNA binding, and anion sensor properties, of a Schiff base, that is, (E)-2-[(6-methoxybenzo[d]thiazol-2-ylimino)methyl]phenol from the reaction of 2-hydroxybenzaldehyde with 2-amino-6-methoxybenzothiazole. Colorimetric measurements revealed that the title compound was sensitive to F⁻, AcO⁻, CN⁻, and OH⁻ anions. Fluorescence measurements demonstrated that the title compound can be used to detect CN⁻. The interactions between the receptor and anions were confirmed using ¹H NMR titration method. The UV–Vis spectroscopy studies of the interactions between the compound and calf thymus DNA (CT-DNA) revealed intercalative binding of CT-DNA to the title compound.