The effects of cyclosporine A and tacrolimus in in vitro culture medium were investigated.
The embryos were evaluated morphologically after 48 h culture period corresponding to 11.5 days of gestation.
Both cyclosporine A and tacrolimus were observed to have dose-dependent toxic and teratogenic effects on embryos.
Prednisolone increases the toxic effects of cyclosporine A, and increases teratogenic effects of tacrolimus.