Investigation of developmental toxicity and teratogenicity of cyclosporine A, tacrolimus and their combinations with prednisolone
详细信息 查看全文
- 作者：Nadire Unver Dogana ; nunver2003@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Ismihan Ilknur Uysala ; Zeliha Fazliogullaria ; Ahmet Kagan Karabuluta ; Hasan Acarb
- 关键词：Cyclosporine A ; Tacrolimus ; Prednisolone ; In vitro embryo culture ; Apoptosis
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：213-222
- 全文大小：2618 K
文摘
- •
The effects of cyclosporine A and tacrolimus in in vitro culture medium were investigated.
- •
The embryos were evaluated morphologically after 48 h culture period corresponding to 11.5 days of gestation.
- •
Both cyclosporine A and tacrolimus were observed to have dose-dependent toxic and teratogenic effects on embryos.
- •
Prednisolone increases the toxic effects of cyclosporine A, and increases teratogenic effects of tacrolimus.