Drug-resistant tuberculosis viewed from bacterial and host genomes
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- 作者：Imen Ben-Kahla ; Sahal AL-Hajoj ; hajoj@kfshrc.edu.sa" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mycobacterium tuberculosis ; Drug resistance ; Molecular biology
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：48
- 期：4
- 页码：353-360
- 全文大小：350 K
文摘
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Emergence of MTB strains resistant to anti-tuberculosis drugs constitutes a serious threat to global TB control.
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TB outcome is the result of complex host–pathogen interactions as human and MTB genetic background play an important role. Whether the interaction influences the selection and expansion of drug-resistant TB represent a primary focus of this review.
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We outline the main and recent findings regarding MTB determinants implicated in the development of drug resistance.
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We examine data regarding human genetic factors that may play a role in TB drug resistance.
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We highlight interesting openings for TB research and therapy.