Resting state functional network disruptions in a kainic acid model of temporal lobe epilepsy
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- 作者：Ravnoor Singh Gill<sup>asup><sup> ; sup><sup>fsup><sup> ; sup><sup>rsing96@uwo.casup> ; Seyed M. Mirsattari<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>csup><sup> ; sup><sup>dsup><sup> ; sup><sup>esup><sup> ; sup><sup>Seyed.Mirsattari@lhsc.on.casup> ; L. Stan Leung<sup>asup><sup> ; sup><sup>fsup><sup> ; sup><sup>sleung@uwo.casup>
- 关键词：Temporal lobe epilepsy ; Limbic system ; Default mode network ; Resting-state networks ; Kainic acid ; Functional connectivity
- 刊名：NeuroImage: Clinical
- 出版年：2017
- 出版时间：2017
- 年：2017
- 卷：13
- 期：Complete
- 页码：70-81
- 全文大小：1894 K
- 卷排序：13
文摘
fMRI was performed on a rat temporal lobe epilepsy (TLE) model induced by kainic acid. Functional connectivity increases in limbic and default mode networks of TLE model. Graph topological properties differ significantly between epileptic and control rats. TLE model shows increased clustering and small-worldness, but similar path length. Isoflurane anaesthetic dose-dependently affects functional connectivity.