Dimethyl-β-cyclodextrin/salazosulfapyridine inclusion complex-loaded chitosan nanoparticles for sustained release
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- 作者：Peixiao Tang ; Hongqin Yang ; Bin Tang ; Di Wu ; Qiaohong Du ; Kailin Xu ; Hui Li ; lihuilab@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Salazosufapyridine ; 2 ; 6-dimethyl-β-cyclodextrin ; Chitosan ; Nanoparticles ; Sustained release
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：20 January 2017
- 年：2017
- 卷：156
- 期：Complete
- 页码：215-222
- 全文大小：1790 K
文摘
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Job’s plot confirmed the 1:1 stoichiometry of the DMβCD/SASP inclusion complex.
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FT-IR, NMR, PXRD, DSC, and SEM analysis confirmed the complex formation.
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The DMβCD/SASP/CS NPs showed higher EE and LE than the SASP/CS NPs.
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An obvious sustained-release manner of SASP was gained by the DMβCD/SASP/CS NPs.
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The DMβCD/SASP/CS NPs exhibited lower toxic to LO2 cells than free SASP.