A novel method for imaging the pharmacological effects of antibiotic treatment on Clostridium difficile
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- 作者：Bradley T. Endresa ; 1 ; Eugé ; nie Bassè ; resa ; 1 ; Ali Memarianic ; Long Changb ; M. Jahangir Alama ; Richard J. Vickersd ; Ioannis A. Kakadiarisc ; Kevin W. Gareya ; kgarey@central.uh.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Clostridium difficile ; Scanning electron microscopy ; Antibiotics ; Metronidazole ; Vancomycin ; Fidaxomicin ; Ridinilazole
- 刊名：Anaerobe
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：10-14
- 全文大小：962 K
文摘
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Comparison of four Clostridium difficile active antibiotics: vancomycin, metronidazole, fidaxomicin, and ridinilazole.
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Semi-automatic analysis pipeline of bacterial SEM images demonstrates different antibiotics have altering effects on the cell wall and cell length.
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This study highlights the utility of this strategy for determining the killing action of different antibiotics.