GDF1 is a novel mediator of macrophage infiltration in brown adipose tissue of obese mice
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- 作者：Yuki Onishi1 ; Kazuya Fukasawa1 ; Kakeru Ozaki ; Takashi Iezaki ; Yukio Yoneda ; Eiichi Hinoi ; hinoi@p.kanazawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALK ; activin-like kinase ; BAT ; brown adipose tissue ; BMP ; bone morphogenic protein ; BSA ; bovine serum albumin ; DMEM ; Dulbecco&rsquo ; s modified Eagle medium ; ER ; endoplasmic reticulum ; GDF ; growth differentiation factor ; HFD ; high fat diet ; PCR ; polymerase chain reaction ; PPARγ ; peroxisome proliferator-activated receptor-γ ; UCP1 ; uncoupling protein-1 ; WAT ; white adipose tissue ; WT ; wild-type
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：5
- 期：Complete
- 页码：216-223
- 全文大小：1767 K
文摘
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GDF1 expression is downregulated in BAT of obese mice.
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GDF1 expression is decreased in brown adipocytes by oxidative and ER stress.
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GDF1 does not alter brown adipogenesis.
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GDF1 accelerates migration of macrophages through the BMP receptor.