Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain
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- 作者：Kalavathi Dasuri
- 关键词：Brain ; Aging ; High fat diet ; Obesity ; Neurodegenerative disorders ; mTOR pathway ; Donepezil ; Neuroinflammation
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1862
- 期：2
- 页码：274-283
- 全文大小：2218 K
文摘
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- <p id="p0005">This is the first study demonstrating the effects of short-term administration of HFD and donepezil on neuroinflammation and mTOR signaling pathway in the brain.p>
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- <p id="p0010">This study demonstrates the role of donepezil in suppressing the HFD induced effects on neuroinflammation.p>
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- <p id="p0015">This study suggests that donepezil restores the levels of mTOR pathway proteins in the mice fed on HFD likely through its suppressing effects on microglial activation.p>