Lytic infection with vaccinia virus activates caspases in a Bcl-2-inhibitable manner
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- 作者：Marie Kalbacova ; Martina Spisakova ; Jana Liskova ; Zora Melkova
- 关键词：Vaccinia virus ; Caspase activation ; Lytic infection ; Necrosis ; Apoptosis ; Flow cytometry
- 刊名：Virus Research
- 出版年：2008
- 出版时间：July 2008
- 年：2008
- 卷：135
- 期：1
- 页码：53-63
- 全文大小：1757 K
文摘
Vaccinia virus (VV) is considered to cause lytic infection of most cells, with lysis being regarded equivalent to necrosis. Activation of caspases has not been associated with necrosis. However, we observed the activation and activity of caspases in epithelial cells HeLa G and BSC-40 lytically infected with VV.