Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae-derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age

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• 作者：Roman Prymula ; Pavla Kriz ; Eva Kaliskova ; Thierry Pascal ; Jan Poolman ; Lode Schuerman
• 关键词：Nasopharyngeal carriage ; Streptococcus pneumoniae ; Haemophilus influenzae ; Pneumococcal protein D conjugate vaccine ; Acute otitis media
• 刊名：Vaccine
• 出版年：2009
• 出版时间：10 December 2009
• 年：2009
• 卷：28
• 期：1
• 页码：71-78
• 全文大小：467 K

文摘

Following primary and booster vaccination with an 11-valent pneumococcall protein D conjugate vaccine there was a 42.8 % (95 % CI: −16.7 to 71.9, ns) reduction in the carriage of Streptococcus pneumoniae vaccine serotypes and a 42.6 % (95 % CI: 1.3–66.6) reduction in the carriage of Haemophilus influenzae identified by standard microbiological techniques. When PCR and immunoblot assays were used to further improve specificity of non-typeable H. influenzae strain identification, carriage of H. influenzae was still reduced with 38.6 % (95 % CI: −6.3 to 64.6, ns). Reduction of acute otitis media (AOM) episodes preceded the impact on carriage. These data provide further support of the functional role of the protein D immunity.