The impact of bone morphogenetic protein 4 (BMP4) on breast cancer metastasis in a mouse xenograft model
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- 作者：M. Ampujaa ; E.L. Alarmoa ; P. Owensb ; R. Havunena ; A.E. Gorskab ; H.L. Mosesb ; A. Kallioniemia ; anne.kallioniemi@uta.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bone morphogenetic protein ; BMP4 ; Breast cancer ; In vivo metastasis model ; Bioluminescence imaging
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：375
- 期：2
- 页码：238-244
- 全文大小：2864 K
文摘
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First study to assess the direct impact of BMP4 on breast cancer metastasis.
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BMP4 treatment resulted in a slightly accelerated metastasis formation.
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BMP4-treated mice had more bone and less adrenal gland metastases compared to controls.
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BMP4 did not cause any changes in the tumor or stroma characteristics.
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The induction of bone metastases may have clinical relevance.