- 作者：Koji Kamagata ; Hiroyuki Tomiyama ; Yumiko Motoi ; Masayoshi Kano ; Osamu Abe ; Kenji Ito ; Keigo Shimoji ; Michimasa Suzuki ; Masaaki Hori ; Atsushi Nakanishi ; Ryohei Kuwatsuru ; Keisuke Sasai ; Shigeki Aoki ; Nobutaka Hattori
- 关键词：Parkinson disease ; Diffusional kurtosis imaging ; Diffusion tensor imaging ; Cingulate fiber ; Tract-specific analysis
- 刊名：Magnetic Resonance Imaging
- 出版年：2013
- 出版时间：November, 2013
- 年：2013
- 卷：31
- 期：9
- 页码：1501-1506
- 全文大小：893 K
Objective
The pathological changes in Parkinson disease begin in the brainstem; reach the limbic system and ultimately spread to the cerebral cortex. In Parkinson disease (PD) patients, we evaluated the alteration of cingulate fibers, which comprise part of the limbic system, by using diffusional kurtosis imaging (DKI).Methods
Seventeen patients with PD and 15 age-matched healthy controls underwent DKI with a 3-T MR imager. Diffusion tensor tractography images of the anterior and posterior cingulum were generated. The mean kurtosis (MK) and conventional diffusion tensor parameters measured along the images in the anterior and posterior cingulum were compared between the groups. Receiver operating characteristic (ROC) analysis was also performed to compare the diagnostic abilities of the MK and conventional diffusion tensor parameters.
Results
The MK and fractional anisotropy (FA) in the anterior cingulum were significantly lower in PD patients than in healthy controls. The area under the ROC curve was 0.912 for MK and 0.747 for FA in the anterior cingulum. MK in the anterior cingulum had the best diagnostic performance (mean cutoff, 0.967; sensitivity, 0.87; specificity, 0.94).
Conclusions
DKI can detect alterations of the anterior cingulum in PD patients more sensitively than can conventional diffusion tensor imaging. Use of DKI can be expected to improve the ability to diagnose PD.