Phase I/II Trial of Dose-Escalated Busulfan Delivered by Prolonged Continuous Infusion in Allogeneic Transplant Patients
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- 作者：Thomas C. Shea1 ; 2 ; sheat@med.unc.edu" class="auth_mail" title="E-mail the corresponding author ; Christine Walko3 ; Yunro Chung4 ; Anastasia Ivanova2 ; 4 ; Julia Sheets1 ; Kamakshi Rao1 ; Don Gabriel1 ; 2 ; Terry Comeau5 ; William Wood1 ; 2 ; James Coghill1 ; 2 ; Paul Armistead1 ; 2 ; Stefanie Sarantopoulos6 ; Jonathan Serody1 ; 2
- 关键词：Busulfan ; Allogeneic ; Pharmacokinetics ; Dose escalation
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：21
- 期：12
- 页码：2129-2135
- 全文大小：538 K
文摘
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Determination of an AUC MTD with continuous-infusion busulfan in allogeneic transplantation.
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Identification of rash and mucositis as the DLTs of high-dose continuous infusion busulfan.
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Potential increased efficacy with an increased AUC of busulfan given as a continuous infusion.