Functional involvement of Ca²⁺ and Ca²⁺-activated K⁺ channels in anethol-induced changes in Ca²⁺ dependent excitability of F1 neurons in Helix aspersa

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• 作者：Zahra Ghasemi^a ; ^b ; Majid Hassanpour-Ezatti^b ; Mohammad Kamalinejad^c ; Mahyar Janahmadi^a ; ^{mjanahmadi@yahoo.com"" rel=""nofollow} ; ^{Janahmadi@sbmu.ac.ir"" rel=""nofollow}
• 关键词：Anethol ; Ca²⁺ spike ; Intracellular recording ; Helix aspersa ; Ca²⁺ channels ; Ca²⁺-activated K⁺ channels
• 刊名：Fitoterapia
• 出版年：2011
• 出版时间：July 2011
• 年：2011
• 卷：82
• 期：5
• 页码：750-756
• 全文大小：610 K

文摘

The effects of anethol, the major component of anise oil, on the Ca²⁺-dependent excitability and afterhyperpolarization (AHP) in snail neurons were examined using intracellular recording. Anethol (0.5 % ) significantly broadened the spike, reduced the firing frequency and enhanced the AHP amplitude. In contrast, anethol (2 % ) significantly increased the firing frequency and decreased the AHP. Blockade of Ca²⁺ channels after anethol application depolarized the membrane potential and significantly reduced the firing rate. Furthermore, in the presence of anethol (0.5 % ) a significant decrease in the AHP was observed by Ca²⁺ channels blockage. Here, anethol-induced functional modification of Ca²⁺ and Ca²⁺-activated K⁺ channels is suggested.