Synthesis and SAR of 2-Phenoxypyridines as novel c-Jun N-terminal kinase inhibitors

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• 作者：Xinyi  ; Song ; Weimin  ; Chen ; Li  ; Lin ; Claudia H.  ; Ruiz ; Michael D.  ; Cameron ; Derek R.  ; Duckett ; Theodore M.  ; Kamenecka  ; ;   ; ^{kameneck@scripps.edu}
• 关键词：c-Jun ; JNK ; Kinase inhibitor ; Phenoxypyridine
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2011
• 出版时间：1 December 2011
• 年：2011
• 卷：21
• 期：23
• 页码：7072-7075
• 全文大小：528 K

文摘

The design and synthesis of a novel series of c-jun N-terminal kinase (JNK3) inhibitors is described. The development and optimization of the 2-phenoxypyridine series was carried out from an earlier pyrimidine series of JNK1 inhibitors. Through the optimization of the scaffold 2, several potent compounds with good in vivo profiles were discovered.