Cx43 increases serum induced filopodia formation via activation of p21-activated protein kinase 1
详细信息 查看全文
- 作者：Petra Kameritscha ; b ; kameritsch@lmu.de" class="auth_mail" title="E-mail the corresponding author ; Felizitas Kiemera ; felizitas.kiemer@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Heike Becka ; Heike.Beck@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Ulrich Pohla ; b ; c ; upohl@lmu.de" class="auth_mail" title="E-mail the corresponding author ; Kristin Pogodaa ; b ; kristin.pogoda@lrz.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aa ; amino acids ; Cx ; connexin ; CT ; C-terminal part ; Hsp27 ; heat shock protein 27 ; NT ; N-terminal part ; PAK1 ; p21-activated protein kinase 1
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：1853
- 期：11
- 页码：2907-2917
- 全文大小：1887 K
文摘
- •
Cx43 enhances filopodia formation in a channel independent manner.
- •
Activation of PAK1 and p38 is required for enhanced filopodia formation.
- •
Interaction of Cx43 with PAK1 is associated with increased phosphorylation of PAK1.
- •
Cx43 enhances phosphorylation of the p38 target Hsp27.
- •
Cx43 augments migration and filopodia formation via activation of PAK1/p38/Hsp27.