Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier

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• 作者：Yasunobu Arima¹ ; Masaya Harada¹ ; Daisuke Kamimura¹ ; Jin-Haeng Park¹ ; Fuminori Kawano² ; Fiona  ; E. Yull³ ; Tadafumi Kawamoto⁵ ; Yoichiro Iwakura⁶ ; Ulrich  ; A.K. Betz⁷ ; Gabriel Má ; rquez⁸ ; ¹⁰ ; Timothy  ; S. Blackwell³ ; ⁴ ; Yoshinobu Ohira² ; Toshio Hirano¹ ; ⁹ ; Masaaki Murakami¹ ; ^{murakami@molonc.med.osaka-u.ac.jp}
• 刊名：Cell
• 出版年：2012
• 出版时间：3 February 2012
• 年：2012
• 卷：148
• 期：3
• 页码：447-457
• 全文大小：1015 K

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Summary

Although it is believed that neural activation can affect immune responses, very little is known about the neuroimmune interactions involved, especially the regulators of immune traffic across the blood-brain barrier which occurs in neuroimmune diseases such as multiple sclerosis (MS). Using a mouse model of MS, experimental autoimmune encephalomyelitis, we show that autoreactive T?cells access the central nervous system via the fifth lumbar spinal cord. This location is defined by IL-6 amplifier-dependent upregulation of the chemokine CCL20 in associated dorsal blood vessels, which in turn depends on gravity-induced activation of sensory neurons by the soleus muscle in the leg. Impairing soleus muscle contraction by tail suspension is sufficient to reduce localized chemokine expression and block entry of pathogenic T?cells at the fifth lumbar cord, suggesting that regional neuroimmune interactions may offer therapeutic targets for a variety of neurological diseases.