SHP-1 is directly activated by the aryl hydrocarbon receptor and regulates BCL-6 in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
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- 作者：Ashwini S. Phadnis-Moghea ; b ; Jinpeng Lia ; b ; Robert B. Crawfordb ; c ; Norbert E. Kaminskib ; c ; kamins11@msu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AHR ; aryl hydrocarbon receptor ; TCDD ; 2 ; 3 ; 7 ; 8-Tetrachlorodibenzo-p-dioxin ; DRE ; dioxin response element ; CD40L ; CD40 ligand ; BCR ; B cell receptor ; SHP-1 ; Src homology phosphatase-1 ; PTPN6 ; protein tyrosine phosphatase ; non-receptor type 6 ; BCL-6 ; B cell lymphoma-6
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：310
- 期：Complete
- 页码：41-50
- 全文大小：1365 K
文摘
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SHP-1 encoded by the gene PTPN6 is directly activated by the AHR.
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AHR binds to dioxin response elements within the SHP-1 promoter in a TCDD-inducible manner.
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TCDD-mediated increase in SHP-1 levels is observed in primary human B cells.
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Higher SHP-1 levels help in maintaining high BCL-6 levels in the presence of TCDD.
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In the presence of SHP-1 inhibitor, decreased BCL-6 levels are observed.