Longevity-associated mitochondrial DNA 5178 A/C polymorphism influences effects of cigarette smoking on serum protein fraction levels in Japanese men

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• 作者：Kokaze ; Akatsuki ; Ishikawa ; Mamoru ; Matsunaga ; Naomi ; Yoshida ; Masao ; Sekine ; Yasuko ; Sekiguchi ; Kanako ; et. al.
• 关键词：Longevity ; Mitochondrial DNA polymorphism ; Smoking habit ; Globulin ; Albumin
• 刊名：Mechanisms of Ageing and Development
• 出版年：2003
• 出版时间：June, 2003
• 年：2003
• 卷：124
• 期：6
• 页码：765-770
• 全文大小：185 K

文摘

Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is reportedly associated with longevity and susceptibility to age-related diseases in Japanese individuals. We previously reported an association between mt5178 A/C polymorphism and serum protein fraction levels in healthy Japanese women. An association between habitual smoking and serum protein fraction levels has also been reported previously. The aim of this study was to examine whether mt5178 A/C polymorphism influenced the effects of habitual smoking on serum protein fraction levels in 321 healthy Japanese men. In mt5178C genotype men, alpha-1 and alpha-2 globulin levels were higher in smokers than in nonsmokers (P<0.001, and P