Haploidentical and Matched Sibling Donor Hematopoietic Cell Transplantation for Patients with HLA-Homozygous Haplotypes
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- 作者：Junya Kanda1 ; Kazuhiro Ikegame2 ; Shigeo Fuji3 ; Mineo Kurokawa4 ; Heiwa Kanamori5 ; Takahiro Fukuda3 ; Kazuteru Ohashi6 ; Jun Ishikawa7 ; Hiroyasu Ogawa2 ; Masami Inoue8 ; Tatsuo Ichinohe9 ; Yoshiko Atsuta10 ; 11 ; Yoshinobu Kanda1 ; 12 ; ycanda-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author ; on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation
- 关键词：Donor selection ; HLA-homozygous haplotypes ; HLA mismatch ; GVHD ; Overall survival ; Host-versus-graft direction
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：22
- 期：11
- 页码：2031-2037
- 全文大小：947 K
文摘
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For patients with homozygous haplotypes, haploidentical donors have no GVH mismatch.
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Transplant outcomes were similar between hetero-to-homo and matched sibling HCT.
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Incidences of acute GVHD and NRM were low after homo-to-homo transplantation.
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Hetero-to-homo transplantation without T cell depletion is a viable option.