8-(1-Naphthalen-2-yl-vinyl)-6,7,10-trioxaspiro (4.5) decane, a new 1,2,4-trioxane effective against rodent and simian malaria

详细信息    查看全文

• 作者：Chandan Singh ; Rani Kanchan ; Divya Srivastava and Sunil K. Puri
• 关键词：Artemisinin ; 1 ; 2 ; 4-Trioxanes ; Rodent malaria ; Simian malaria
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 出版时间：1 February 2006
• 年：2006
• 卷：16
• 期：3
• 页码：584-586
• 全文大小：105 K

文摘

A new series of 8-(1-aryl-vinyl)-6,7,10-trioxaspiro [4.5] decanes 7a–e and 3-(1-aryl-vinyl)-l,2,5-trioxaspiro [5.5] undecanes 8a–e have been prepared and screened against multi-drug resistant Plasmodium yoelii in mice. 8-(1-Naphthalen-2-yl-vinyl)-6,7,10-trioxaspiro [4.5] decane 7b, the most active trioxane of the series, has also shown promising activity against Plasmodium cynomolgi in rhesus monkeys.