Association of the C47T polymorphism in superoxide dismutase gene 2 with noise-induced hearing loss: a meta-analysis

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• 作者：Jing Wang^a ; ^b ; ^{wangjing1807@foxmail.com} ; Jun Li^b ; ^c ; Kang Peng^a ; Zi-Ying Fu^a ; Jia Tang^a ; Ming-Jian Yang^a ; Qi-Cai Chen^a ; ^{chenqc@mail.ccnu.edu.cn}
• 关键词：Superoxide dismutase gene 2 ; Polymorphism ; Noise-induced hearing loss ; Meta-analysis
• 刊名：Brazilian Journal of Otorhinolaryngology
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：83
• 期：1
• 页码：80-87
• 全文大小：1457 K
• 卷排序：83

文摘

Currently, there is limited information about the relationship between manganese superoxide dismutase (sod2) c47t polymorphism and susceptibility to noise-induced hearing loss (NIHL).ObjectiveThe aim of this meta-analysis was to clarify the association between SOD2 C47T polymorphism and NIHL.MethodsA search in PubMed and Web of Science was performed to collect data. All full-text, English-written studies containing sufficient and complete case-and-control data about the relationship between SOD2 C47T polymorphism and NIHL were included. Three eligible studies, comprising 1094 subjects, were identified. pooled odds ratios (ORs) and 95% confidence intervals (CI) were calculated to evaluate the strength of the association between SOD2 C47T polymorphism and NIHL.ResultsNo significant association between C47T polymorphism and risk of NIHL was found with the following combinations: T vs. C (OR = 0.83; 95% CI = 0.63–1.09); TT vs. CC (OR = 0.49; 95% CI = 0.22–1.09); CT vs. CC (OR = 0.54; 95% CI = 0.25–1.17); TT vs. CC + CT (OR = 0.82; 95% CI = 0.50–1.32); CC vs. TT + TC (OR = 0.49; 95% CI = 0.23–1.04). However, in subgroup analysis, a significant association was found for TT vs. CC + CT (OR = 0.77; 95% CI = 0.42–1.41) in the Chinese population.ConclusionThe present meta-analysis suggests that SOD2 C47T polymorphism is significantly associated with increased risk of NIHL in the Chinese population. Further large and well-designed studies are needed to confirm this association.