Mechanically tuned nanocomposite coating on titanium metal with integrated properties of biofilm inhibition, cell proliferation, and sustained drug delivery

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• 作者：Sandeep K. Mishra ; MSc^a ; Arun K. Teotia ; MS^b ; Ashok Kumar ; PhD^b ; Sanjeevi Kannan ; PhD^a ; ^{para_kanna@yahoo.com}
• 关键词：Microwave synthesis ; Silver nanoparticles ; Nanohybrid ; Chitosan ; Nanoindentation ; Naproxen
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：13
• 期：1
• 页码：23-35
• 全文大小：3337 K
• 卷排序：13

文摘

Microwave synthesis of silver nanoparticles cored in poly vinyl alcohol nanocapsules (Ag-PVA NCs). Ag-PVA NCs reinforced chitosan matrix used for mechanically tuned coating on titanium implant. Coating expressed intrinsic property of biofilm inhibition due to AgNP presence. Achievement of dual tuned drug release due to differential entrapment of drug in PVA polymeric shell of AgNPs and CS matrix. Adhesion, proliferation and differentiation of osteoblast tests demonstrated the efficacy of Ag-PVA NCs.