Immune responses following one and two doses of the reformulated, bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata, India: A randomized, placebo-controlled trial

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• 作者：Suman Kanungo ; Allison Paisley ; Anna Lena Lopez ; Mihir Bhattacharya ; Byomkesh Manna ; Deok Ryun Kim ; Seung Hyun Han ; Stephen Attridge ; Rodney Carbis ; Raman Rao ; Jan Holmgren ; John D. Clemens ; Dipika Su
• 关键词：Cholera ; Vaccine ; Immunogenicity ; Safety ; India
• 刊名：Vaccine
• 出版年：2009
• 出版时间：16 November 2009
• 年：2009
• 卷：27
• 期：49
• 页码：6887-6893
• 全文大小：343 K

文摘

Immune responses after one and two doses of the reformulated killed oral cholera vaccine were measured in a double-blind, randomized, placebo-controlled trial of 77 adults aged 18–40 years and 77 children aged 1–17 years residing in Kolkata, India. 65 % of adults and 87 % of children and 46 % of adults and 82 % of children exhibited a ≥4-fold rise in serum Vibrio cholerae O1 vibriocidal antibody titers from baseline following dose 1 and 2, respectively. Responses to V. cholerae O139 were less pronounced but followed a similar pattern. We demonstrate that in a cholera-endemic area, the vaccine elicited vibriocidal responses after a single-dose of the vaccine.