Revisiting the regulatory roles of the TGF-β family of cytokines

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• 作者：Keshi Fujio ; ^{kfujio-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Toshihiko Komai ; Mariko Inoue ; Kaoru Morita ; Tomohisa Okamura ; Kauzhiko Yamamoto
• 关键词：B cell ; Regulatory T cell ; TGF-beta ; Integrin
• 刊名：Autoimmunity Reviews
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：15
• 期：9
• 页码：917-922
• 全文大小：299 K

文摘

TGF-β family members are multipotent cytokines that are involved in many cellular processes, including cell differentiation, organ development, wound healing and immune regulation. TGF-β has pleiotropic effects on adaptive immunity, especially in the regulation of CD4⁺ T cell and B cell responses. Furthermore, identification of CD4⁺ T cell subsets that produce TGF-β3 revealed unexpected roles of TGF-β3 in the control of adaptive immunity. In contrast to TGF-β1, which induces extensive fibrosis, TGF-β3 induces non-scarring wound healing and counteracts tissue fibrosis. Recent progress in the understanding of the activation mechanism of TGF-β may enable us to develop novel biologic therapies based on advanced protein engineering.