The association between functional HLA-G 14 bp insertion/deletion and +3142 C > G polymorphisms and susceptibility to multiple sclerosis

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• 作者：Nadia Ben Fredj^a ; ^{benfredj_nadia@yahoo.fr} ; Kaouthar Sakly^b ; Daria Bortolotti^c ; Mouna Aissi^d ; Mahbouba Frih-Ayed^d ; Antonella Rotola^c ; Elisabetta Caselli^c ; Franscesca Cura^c ; Nabil Sakly^b ; Mahjoub Aouni^a ; Dario Di Luca^c ; Roberta Rizzo^c
• 关键词：ADO ; age of disease onset ; bp ; base pairs ; CI ; confidence interval ; CNS ; central nervous system ; CSF ; cerebrospinal fluids ; EDSS ; expanded disability status scale ; HD ; healthy volunteer blood donors ; HLA ; human leukocyte antigen ; HWE ; Hardy-Weinberg equilibrium ; IL ; interleukin ; INS/DEL ; insertion/deletion ; LD ; linkage disequilibrium ; MHC ; major histocompatibility complex ; MRI ; magnetic resonance imaging ; MS ; multiple sclerosis ; OR ; odds ratio ; PCR ; polymerase chain reaction ; RR-MS ; relapsing re
• 刊名：Immunology Letters
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：180
• 期：Complete
• 页码：24-30
• 全文大小：697 K
• 卷排序：180

文摘

A significant increased frequencies of the +3142 G allele and the 14 bp DEL / +3142 G haplotype were found in MS patients compared to HD. MS patients with the +3142 C/C genotype have lower age of disease onset (ADO). The +3142 C > G polymorphism may constitute a genetic susceptibility factor to MS in the Tunisian population. No association was found between the two polymorphisms and sHLA-G serum levels.