TRIM52 selectively activates NF-κB activity. RING-domain is essential for TRIM52-mediated NF-κB activation. TRIM52 overexpression do not affect the changes in IκBα and phosphorylated p6 protein levels. NF-κB inhibitors have no effect on TRIM52-mediated NF-κB activation. TRIM52 mRNA expression was induced by pro-inflammatory cytokines.