Lower carotid intima media thickness is predicted by higher serum bilirubin in both non-diabetic and Type 2 diabetic subjects

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• 作者：Robin P.F. Dullaart ; ^{r.p.f.dullaart@int.umcg.nl} ; Paul J.W.H. Kappelle ; Rindert de Vries
• 关键词：Bilirubin ; Intima media thickness ; Transaminases ; Type 2 diabetes mellitus
• 刊名：Clinica Chimica Acta
• 出版年：2012
• 出版时间：24 December, 2012
• 年：2012
• 卷：414
• 期：Complete
• 页码：161-165
• 全文大小：224 K

文摘

<h4 class=""h4"">Backgroundh4>Higher serum bilirubin levels may be implicated cardiovascular protection. It is unknown whether the impact of serum bilirubin on carotid artery intima media thickness (IMT), a marker of subclinical atherosclerosis, is different in diabetic subjects compared to non-diabetic subjects. We assessed relationships of IMT with serum total bilirubin in non-diabetic and Type 2 diabetic subjects without clinically manifest cardiovascular disease.<h4 class=""h4"">Methodsh4>

IMT, total bilirubin, transaminases, C-reactive protein (CRP) and lipid levels were measured in 40 predominantly middle-aged non-diabetic and 80 diabetic subjects.<h4 class=""h4"">Resultsh4>

IMT was higher in diabetic subjects compared to non-diabetic subjects (unadjusted, p < 0.001), whereas bilirubin was not different (p = 0.82). In both non-diabetic and in diabetic subjects, IMT was negatively related to bilirubin (¦Â = ? 0.316, p = 0.045 and ¦Â = ? 0.247 p = 0.014, respectively) taking account of age, sex and mean arterial pressure. In the combined subjects, IMT remained independently related to bilirubin (¦Â = ? 0.183, p = 0.028) after additional adjustment for diabetes status, alcohol intake, transaminases, CRP and lipid levels. There was no interaction of bilirubin with the presence of diabetes on IMT (p = 0.98).<h4 class=""h4"">Conclusionh4>

Carotid artery IMT relates negatively to bilirubin in non-diabetic and Type 2 diabetic subjects. The association of subclinical atherosclerosis with bilirubin appears to be unaltered in the diabetic state.