The Effect of Therapeutic Ultrasound on Metallic Implants: A Study in Rats

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• 作者：Barış Kocaoğlu ; MD^a ; ^{bariskocaoglu@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Cengiz Ç ; abukoglu ; MD^b ; Nadire Ö ; zeras ; MD^c ; Mustafa Seyhan ; MD^e ; Mustafa Karahan ; MD^d ; Selim Yalcin ; MD^d
• 关键词：Bone Fracture healing ; implant failure ; metal ; Heating ; Loosening ; Metallic implant ; Rehabilitation ; Ultrasound
• 刊名：Archives of Physical Medicine and Rehabilitation
• 出版年：2011
• 出版时间：November 2011
• 年：2011
• 卷：92
• 期：11
• 页码：1858-1862
• 全文大小：579 K

文摘

Kocaoğlu B, Çabukoglu C, Özeras N, Seyhan M, Karahan M, Yalcin S. The effect of therapeutic ultrasound on metallic implants: a study in rats.

Objective

To investigate whether therapeutic ultrasound (US) use over metallic implants has the potential for adverse effects as a result of greater temperature increases at the tissue-metal interface.

Design

A randomized controlled trial.

Setting

A research laboratory.

Animals

Sprague-Dawley rats (N=40; weight, 230–300g) were used and divided into 3 study groups.

Interventions

In group 1, both limbs of 10 rats were used for evaluation of temperature changes. Metal pins were placed into the femur of the left limb, and the right limbs were used as controls. A thermal sensor was placed into the medulla to record the elevation of tissue temperature during US application. In groups 2 and 3 with 15 rats in each, a midshaft femoral fracture was produced, and intramedullary fixation was performed with metal pins. Group 2 received US treatment for 5 minutes daily and continued for 27 days. Group 3 served as controls.

Main Outcome Measures

The rats in groups 2 and 3 were killed on postoperative day 30. The specimens were evaluated by radiology, histopathology, and biomechanics.

Results

The presence of metal in bone did not cause an increased temperature rise. US application did not increase or decrease callus formation, and there was no tissue necrosis. The average removal torques of pins in groups did not show a significant difference.

Conclusions

Internal fixation with metallic implants may not be a contraindication for therapeutic US treatment.