TRAIL mRNA expression in peripheral blood mononuclear cells of Egyptian SLE patients

详细信息    查看全文

• 作者：Safaa Mostafa El-Karaksy ; Naglaa Mohamed Kholoussi ; Rasha Mohamad Hosny Shahin ; Mona Mohsen Abou El-Ghar ; Rasha El-Sayed Gheith
• 关键词：ANAs ; antinuclear antibodies ; Apo2L ; apoptosis ligand 2 ; C3 ; complement ; CBC ; complete blood count ; DcR1 ; decoy receptor 1 ; DR4 ; death receptor 4 ; dsDNA ; double-stranded deoxyribonucleic acid antibodies ; ESR ; erythrocyte sedimentation rate ; GAPDH ; glycera
• 刊名：Gene
• 出版年：2013
• 出版时间：15 September, 2013
• 年：2013
• 卷：527
• 期：1
• 页码：211-214
• 全文大小：253 K

文摘

Although the definite etiopathogenesis of systemic lupus erythematosus (SLE) remains unclear, many different mechanisms may contribute to its pathogenesis. Tumor-necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) family with pro-apoptotic activity. The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE, and TRAIL may trigger this programmed cell death. We investigated TRAIL mRNA expression levels in peripheral blood mononuclear cells (PBMCs) from 60 SLE patients and 40 controls using quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR), and we studied the association between the results and clinical and laboratory parameters of the patients. Expression levels of TRAIL mRNAs in SLE patients were significantly higher than in controls (p < 0.001). A statistically significant association was detected between TRAIL mRNA expression and SLE activity (p = 0.001).