Testosterone deficiency in young women with 46,XX spontaneous premature ovarian failure

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• 作者：Sophia N. Kalantaridou ; Karim A. Calis ; Vien H. V ; erhoof ; Vladimir K. Bakalov ; Emily C. Corrigan ; James F. Troendle ; Lawrence M. Nelson
• 关键词：Free testosterone ; total testosterone ; premature ovarian failure ; sex hormone– ; binding globulin ; equilibrium dialysis ; ovarian insufficiency
• 刊名：Fertility and Sterility
• 出版年：2006
• 出版时间：November 2006
• 年：2006
• 卷：86
• 期：5
• 页码：1475-1482
• 全文大小：194 K

文摘

Objective

To determine whether women with 46,XX spontaneous premature ovarian failure have lower serum free-T levels than do control women.

Design

Cross-sectional.

Setting

National Institutes of Health Clinical Research Center.

Patient(s)

Women with 46,XX spontaneous premature ovarian failure (n = 130).

Intervention(s)

Evaluation while off any estrogen therapy and then again after receiving a standardized hormone regimen. Regularly menstruating control women (n = 65) were sampled during the midfollicular phase.

Main Outcome Measure(s)

Serum total T by RIA after extraction and column chromatography, free T by equilibrium dialysis, and sex hormone–binding globulin by immunoradiometric assay.

Result(s)

While off estrogen therapy patients had a median serum free-T concentration that was statistically significantly lower than controls (2.2 vs. 3.3 pg/mL). This dropped significantly lower to 1.9 pg/mL while the patients were on physiologic transdermal E₂ therapy. This is despite the fact that sex hormone–binding globulin levels did not change. While on E₂ therapy, 13 % of women (95 % confidence interval, 7.9 % –20.3 % ) had serum free-T levels below the lower limit of normal (<1.1 pg/mL).

Conclusion(s)

As a group, young women with 46,XX spontaneous premature ovarian failure have reduced circulating free-T levels, both during an interval off of estrogen therapy and while on physiologic transdermal E₂ therapy.