Cortical inhibitory deficits in premanifest and early Huntington’s disease
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- 作者：April L. Philpotta ; Tarrant D.R. Cumminsa ; Neil W. Baileyb ; Andrew Churchyardc ; Paul B. Fitzgeraldb ; Nellie Georgiou-Karistianisa ; nellie.georgiou-karistianis@monash.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Premanifest Huntington&rsquo ; s disease ; Transcranial magnetic stimulation ; Cortical inhibition ; GABA ; Corticostriatal ; Pathophysiological mechanism
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：296
- 期：Complete
- 页码：311-317
- 全文大小：608 K
文摘
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Understanding pathophysiology in HD may provide new insights on disease mechanisms.
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We studied the largest premanifest and symptomatic HD sample with TMS to date.
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Cortical inhibitory deficits were observed in both premanifest and symptomatic HD.
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Reduced GABAergic inhibition in HD was correlated with the triad of symptomology.
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TMS is a useful tool for investigating pathophysiology in HD.