Cortical inhibitory deficits in Huntington's disease are not influenced by gender
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- 作者：April L. Philpotta ; Tarrant D.R. Cumminsa ; Neil W. Baileyb ; Andrew Churchyardc ; Paul B. Fitzgeraldb ; Nellie Georgiou-Karistianisa ; nellie.georgiou-karistianis@monash.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Transcranial magnetic stimulation ; GABA ; Sex difference
- 刊名：Psychiatry Research: Neuroimaging
- 出版年：2016
- 出版时间：30 November 2016
- 年：2016
- 卷：257
- 期：Complete
- 页码：1-4
- 全文大小：274 K
文摘
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Huntington's disease affects GABAergic function in cortico-subcortical pathways.
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TMS was used to study whether sex modulates pathophysiology in Huntington's disease.
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Cortical inhibition was significantly reduced in symptomatic Huntington's disease.
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Females exhibited significantly reduced cortical inhibition compared with males.
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Sex differences do not interact with inhibitory deficits in Huntington's disease.