Blockade of thymic stromal lymphopoietin (TSLP) receptor inhibits TSLP-driven proliferation and signalling in lymphoblasts from a subset of B-precursor ALL patients
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- 作者：Tina Vettera ; Andreas Borowskia ; 1 ; Andreas Wohlmanna ; Nilabh Ranjana ; Michael Kuepperb ; Susanne Badurac ; Oliver G. Ottmannc ; Karlheinz Friedricha ; karlheinz.friedrich@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：TSLP ; Cytokine receptors ; B-precursor ALL ; Inhibitory antibody
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：38-43
- 全文大小：848 K
文摘
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Lymphoblasts from roughly 20% of B cell precursor ALL patients express the TSLP receptor.
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TSLP triggers proliferation and JAK/STAT-mediated gene regulation in TSLPR+ BCP-ALL cells.
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TSLPR inhibition represses proliferation and STAT activity in TSLPR+ BCP-ALL cells.
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Blockade of the TSLPR is a potential therapeutic option for a subset of BCP-ALL patients.