Maternal preeclampsia and bone mineral density of the adult offspring

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• 作者：Satu Miettola ; Petteri Hovi ; Sture Andersson ; Sonja Strang-Karlsson ; Anneli Pouta ; Hannele Laivuori ; Anna-Liisa J盲rvenp盲盲 ; Johan G. Eriksson ; Outi M盲kitie ; Eero Kajantie
• 关键词：bone ; hypertension ; preeclampsia ; premature birth ; very-low-birthweight
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：November, 2013
• 年：2013
• 卷：209
• 期：5
• 页码：443.e1-443.e10
• 全文大小：563 K

文摘

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Objective

Preterm birth at very low birthweight (<1500 g) is associated with cardiometabolic risk factors and reduced bone mineral density in the adult offspring. Preeclampsia is a frequent cause of preterm birth and is also associated with cardiometabolic risk factors in the offspring. Whether it is associated with bone mineral density is not known.

Study Design

We evaluated skeletal health in participants of the Helsinki Study of Very Low Birthweight Adults: 144 born at very low birthweight and 139 born at term. From the very low birthweight and term offspring a respective 32 and 11 were born from pregnancy complicated by preeclampsia. We measured bone mineral density at age 18.5 to 27.1 years by dual X-ray absorptiometry.

Results

Very low birthweight adults exposed to maternal preeclampsia had higher lumbar spine Z score (mean聽鈭?.44, compared with聽鈭?.07 in very low birthweight unexposed adults, P聽= .002), femoral neck Z score (鈭?.05 vs聽鈭?.53, P聽= .003) and whole body bone mineral density Z score (鈭?.14 vs 鈭?.72, P聽= .001). Corresponding Z scores for those born at term were聽鈭?.02 (preeclampsia) and聽鈭?.45 (no preeclampsia) for lumbar spine (P聽= .2), 0.78 and 0.08 for femoral neck (P聽= .02) and 0.02 and聽鈭?.31 for whole body bone mineral density Z score (P聽= .08). The results survived adjustment for offspring current height, body mass index, leisure time physical activity, socioeconomic position, smoking, and maternal smoking during pregnancy, and maternal prepregnancy body mass index.

Conclusion

Young adults exposed to maternal preeclampsia have higher bone mineral density than those not exposed. This difference is seen among those born at very low birthweight and seems also to be present among those born at term.