5-HT_1A receptor and 5-HTT binding during the menstrual cycle in healthy women examined with [¹¹C] WAY100635 and [¹¹C] MADAM PET

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• 作者：Hristina Jovanovic ; Per Karlsson ; Å ; sta Cerin ; Christer Halldin ; Anna-Lena Nordströ ; m
• 关键词：5-HT_1A receptor ; 5-HTT ; Women ; Menstrual cycle ; Gonadal hormones ; PET
• 刊名：Psychiatry Research: Neuroimaging
• 出版年：2009
• 出版时间：30 April 2009
• 年：2009
• 卷：172
• 期：1
• 页码：31-37
• 全文大小：244 K

文摘

The aim of the present study was to explore the effects of the menstrual cycle phases on 5-HT_1A receptor and 5-HTT binding potentials (BPs) in healthy women by using positron emission tomography (PET). Women were investigated in the follicular and luteal phase of the menstrual cycle with radioligands [¹¹C]WAY10035 (n = 13) and [¹¹C]MADAM (n = 8) to study 5-HT_1A and 5-HTT BPs. The BPs values were quantified using the simplified reference tissue model. The phases of the menstrual cycle were characterized by transvaginal ultrasound (TSV) and plasma levels of hormones estradiol (E₂), progesterone (P₄), follicle stimulating hormone (FSH) and luteinizing hormone (LH).The 5-HT_1A receptor and 5-HTT BPs did not significantly differ between follicular and luteal phases in any of the investigated regions. There were no significant correlations between the change in E₂ or P₄ values with the change in 5-HT_1A receptor or 5-HTT BPs. The results provide principally a new in vivo finding in human female biology, suggesting the absence of influence of menstrual cycle phase on 5-HT_1A receptors or 5-HTT. The finding however does not preclude that gonadal hormones differentially influence central serotonin system inwomen and men, which might contribute to gender differences in serotonin-associated disorders.