An in-vivo study for targeted delivery of copper-organic complex to breast cancer using chitosan polymer nanoparticles
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- 作者：Arindam Pramanika ; Dipranjan Lahaa ; d ; Sandeep Kumar Dashb ; Sourav Chattopadhyayb ; Somenath Royb ; Dipak Kumar Dasc ; Panchanan Pramanikc ; Parimal Karmakara ; pkarmakar_28@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Breast cancer ; Biopolymer ; Copper ; Nanoparticle ; Targeted drug delivery
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：327-337
- 全文大小：2387 K
文摘
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Bis(2,4-pentanedionato)copper(II) was used as breast cancer therapeutics.
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Bis(2,4-pentanedionato)copper(II) was encapsulated into chitosan nanoparticle.
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The nanoparticle was targeted to breast cancer cells using her2 receptor and folate receptor.
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From in-vivo study, the tumor volume decreased whereas the survivability of mice increased.