Single-molecule surface-enhanced Raman spectroscopy from a molecularly-bridged silver nanoparticle dimer

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• 作者：Blanka Vlč ; ková ; Martin Moskovits ; Ioana Pavel ; Karolina &#x160 ; i&#x161 ; ková ; Magdalena Slá ; dková ; Miroslav &#x160 ; louf
• 关键词：Embryonic stem cells ; Hematopoietic stem cells ; Differentiation ; Regulatory niche ; Cytokines ; Stromal cell lines
• 刊名：Chemical Physics Letters
• 出版年：2008
• 出版时间：10 April 2008
• 年：2008
• 卷：455
• 期：4-6
• 页码：131-134
• 全文大小：410 K

文摘

Silver nanoparticle dimers were produced and immobilized on a functionalized TEM finder grid, by sequential assembly using bifunctional molecular linker 4,4′-diaminoazobenzene. SERS spectra recorded were ascribed to the specific dimer by TEM-imaging. Temporal fluctuations (blinking) of SERS signal demonstrate observation of single-molecule Raman. By linker-mediated assembly at small linker to nanoparticle ratios, electromagnetic hot spots are created with one or very few molecular linkers localized in them. Observed recurrence times are consistent with known surface diffusion constants, suggesting that single molecule dynamics causing the blinking might arise from breaking of linker bond to one of the nanoparticles, linker diffusion over the other nanoparticle and return to the hot spot.